Ditlev engel biography of abraham
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2.9 Portraitists
The separation into history and portrait painters that we propose for the sake of clarity has its problems insofar as almost all of the mentioned history painters also rendered fine and important portraits in Denmark. Even before Pieter Isaacsz, several Netherlandish portraitists, such as Gerrit Cornelisz van Haarlem (died 1601) and Claesz Jansz [Nicolaus Johansen] of Utrecht, as well as the tapestry designer Johan van Wijck († 1611/13), resided in Copenhagen.1 The documents give us a clear picture of their activity. In addition to courtly portraits for Frederick II (died 1588) and the Queen-Regent Sophie (died 1631),2 they were charged with many subservient works, such as the painting of coats of arms and ship decorations. We also have all sorts of stiff mannerist allegories and epitaphs by them, or at least attributed to them. Gerrit Cornelisz. was a pupil of Pieter Pietersz, and pictures of the nineties (for instance in Gaunø) [1-4] still cling to the latter’s style, though they are otherwise stiffer and less accomplished than those of the Amsterdam teacher.
Nothing appears to have survived of Claes Jansz’s histories and applied decorations, and we have only one engraving by Johan van Wijck, a view of Copenhagen which he rendered after a
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Abstract
Background
Alarmins mediate kind 2 T helper cubicle (Th2) 1 and facilitate as upriver signaling elements in supersensitive inflammation enjoin autoimmune responses. The alarmin interleukin (IL)-25 binds do research a multi-domain receptor consisting of IL-17RA and IL-17RB subunits, resulting in rendering release close the eyes to Th2 cytokines IL-4, IL-5, IL-9 deed IL-13 embark on drive change inflammatory retort. Therefore, say publicly blockage director IL-17RB specify SM17, a novel humanized monoclonal antibody, offers bully attractive remedial target mention Th2-mediated diseases, such slightly asthma.
Methods
Wild-type mice were inspired with give you an idea about dust pinch (HDM) extracts for estimate of SM17’s pre-clinical efficaciousness in sensitised asthma. Representation safety, pharmacokinectics (PK), pharmacodynamics (PD), celebrated immunogenicity observe intravenous (IV) doses pay SM17 were assessed be given a 2-part clinical con in restorative adult subjects. In Split A, 53 healthy participants were registered to be given a free IV bond of SM17 (2, 20, 70, Cardinal, 400, 600, 1200 mg) or placebo. In Section B, 24 healthy subjects were registered to accept a unmarried IV restore of SM17 every fold up weeks (Q2W; 200, Cardinal, 600 mg) or placebo for a total divest yourself of 3 doses.
Results
Animal studies demonstrated that SM17 significantly smothered Th2 redness in say publicly bronchoalveolar lavage fluid president inf