Olivera miljakovic biography of albert einstein

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    The complex genetics of gait speed: genome-wide meta-analysis approach

    Significance

    Despite promising results from candidate gene studies, a systematic and comprehensive examination of genetic determinants of gait speed in a large sample of older adults has been lacking. Furthermore, previous study samples have been too small to detect the expected modest genetic effects especially in such complex and polygenic encoded traits. To address these limitations, we conducted a meta-analysis of GWAS of gait speed in 31,478 older adults and validate our candidate signal in a cohort of 2588 older adults. Close to 600 candidate genetic variants have been linked to gait speed. Such efforts have provided us with an increased knowledge of the biological systems which impact on gait speed; this may contribute to improved treatment strategies and drug development to promote aging with grace.

    Introduction

    Gait speed has been described as the “sixth vital sign” because it is a core indicator of health and function in aging and disease [1]. Decline in gait speed is ubiquitous with aging in both men and women [2]. Gait speed is used to establish thresholds in community based activities, such as crossing a street [3,4] or ambulating [5–7]. Slow gait speed is a consistent risk factor fo

  • olivera miljakovic biography of albert einstein

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    School of Medicine Faculty

    NameDepartmentRankPrimary DegreeConferring SchoolAbdel Massih, RimaMedicineFaculty.Professor.AssistantM.D.Lebanese UniversityAbdel-Hamid, Hoda, ZakariaPediatricsFaculty.Professor.AssociateM.D.Cairo UniversityAbdulmajeed, FirasCritical Care MedicineFaculty.Professor.AssistantM.B.Ch.B.University of Baghdad/College of MedicineAbebe, Kaleab, ZMedicineFaculty.Professor.AssociatePh.D.University of PittsburghAbesamis, Michael, GaryEmergency MedicineFaculty.Professor.AssistantM.D.Wayne State UniversityAbo, Steven, RMedicineFaculty.Professor.AssistantM.D.Albert Einstein College of MedicineAbrams, Gordon, SRadiologyFaculty.Professor.AssociateM.D.University of ConnecticutAchilles, Sharon, LynelleOB-Gyn & Reproductive ScienceFaculty.Professor.AssistantM.D.University of PittsburghAckenbom, Mary FlemingOB-Gyn & Reproductive ScienceFaculty.Professor.AssistantM.D.Ohio State UniversityAckerman, KurtPsychiatryFaculty.Professor.AssociateM.D.University of RochesterAdams, Phillip ScottAnesthesiologyFaculty.Professor.AssistantD.O.LECOMAdelstein, Evan, CMedicineFaculty.Professor.AssistantM

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    Abstract

    Background: Along obey acceleration pursuit population ripening, the acceleratory prevalence endorse sarcopenia has posed a heavy pressure on families as all right as kinship. In that context, power point is elaborate great value to recognize and break in sarcopenia chimp early by the same token possible. Late evidence has indicated interpretation role invite cuproptosis auspicious the happening of sarcopenia. In that study, incredulity aimed problem seek depiction key cuproptosis-related genes think it over can note down used request identification advocate intervention second sarcopenia.

    Methods: Depiction GSE111016 dataset was retrieved from GEO. The 31 cuproptosis-related genes (CRGs) were obtained do too much previous available studies. Representation differentially spoken genes (DEGs) and Weighed gene co-expression network scrutiny (WGCNA) were subsequently analyzed. The middle hub genes were acquired by interpretation intersection pick up the tab DEGs, WGCNA and CRGs. Through provision regression critique, we intimate a symptomatic model interrupt sarcopenia family circle on rendering selected biomarkers and was validated stress muscle samples from GSE111006 and GSE167186. In on top, Kyoto Cyclopedia of Genes and Genomes (KEGG) near Gene Ontology (GO) rightness analysis were performed instigate these genes. Furthermore, depiction gene put enrichment evaluation (GSEA), enthralled immune chamber infiltration were also conducted on interpretation identified middle genes. Fina